Dr. Krzysztof Lewiński
Professor
Cheimstry
Jagiellonian University
Poland
Biography
Dr. Krzysztof Lewiński is the Professor of Chemistry in Jagiellonian University. His research interest is focused on structural investigations using single crystal X-ray diffraction methods. Among recent projects are: Determination of high-pressure crystal structure of selected proteins (ribonuclease A, insulin, BPTI, hemoglobin, thaumatin), structural origin of decreased pressure and temperature stability of mutated ribonuclease A molecules, Crystal structure of human arylsulfatase A, its enzymatic mechanism and inhibition, specifi city of ligand binding by beta-lactoglobuline, synthesis and structural investigations of new organic compounds with potential biological activity, Structural investigations of mixed-ligand cyanocomplexes of molybdenum and of supramolecular assemblies based on octacyanotungstate(V).
Research Interest
Crystal Chemistry
Publications
-
Chruszcz M., Laidler P., Monkiewicz M., Ortlund E., Lebioda L., Lewiński K., Crystal structure of a covalent intermediate of endogenous human arylsulfatase A, J. Inorg. Biochem., 96, 386–392, 2003.
-
Ciechanowicz-Rutkowska M., Lewiński K., Oleksyn B., Stec B., Model studies of the function of blockers on the small conductance potassium ion channel, J. Pept. Res., 62, 1–9, 2003.
-
Przychodzeń P., Pełka R., Lewiński K., Supel J., Rams M., Tomala K., Sieklucka B., Tuning of magnetic properties of polynuclear lanthanide(III)-octacyanotungstate(V) systems: Determination of ligand-fi eld parameters and exchange interaction, Inorg. Chem., 46, 8924– 8938, 2007.
-
Matoga D., Szklarzewicz J., Lewiński K., Cyanooxo molybdenum(IV) complexes with 2-pyrazinecarbonitrile and 2-pyrazinecarboxylate: Crystallographic and spectroscopic studies reveal metal-assisted nitrile hydrolysis, Polyhedron, 27, 2643–2649, 2008.
-
Chagnault V., Compain P., Lewinski K., Ikeda K., Asano N., Martin O.R., Stereodivergent access to polyhydroxylated 10-azabicyclo[4.3.1]decanes as new calystegine analogs, J. Org. Chem., 74, 3179–3182, 2009.
