anna NiedŹwiecka
professor
physics
Polish Academy of Science
Poland
Biography
"Education • Ph.D. 2003, physical sciences (biophysics), with honors University of Warsaw, Faculty of Physics, Division of Biophysics, Poland Thesis advisor: Ryszard Stolarski Thesis: Thermodynamic analysis of interaction of eIF4E protein with mRNA 5’ cap structure and 4E-BP1 or eIF4G protein fragments • M.Sc., 1994, molecular biophysics, with honors University of Warsaw, Faculty of Physics, Division of Biophysics, Poland Thesis advisor: David Shugar Thesis: Studies of tautomerism and conformation of N4-hydoxy derivatives of methylated cytosine analogs by means of molecular spectroscopy Employment • since 2009 Scientific coordinator of NanoFun Project POIG.02.02.00-00-025/09 in NanoBioGeo consortium (~54 mln PLN) and project manager in Institute of Physics PAS (~12 mln PLN) • since 2004 Laboratory of Biological Physics, Institute of Physics, Polish Academy of Sciences • since 1999 Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw
Research Interest
Interactions and Structural Dynamics of Biomolecules
Publications
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"Selected publications Niedzwiecka A, Nilsson P, Worch R, Stepinski J, Darzynkiewicz E, Virtanen A. Molecular recognition of mRNA 5’ Cap by 3’ poly(A)-specific ribonuclease (PARN) differs from interactions known for other cap-binding proteins. Biochimica et Biophysica Acta 2016; 1864: 331–345. Piecyk K, Niedzwiecka A, Ferenc-Mrozek A, Lukaszewicz M, Darzynkiewicz E, Jankowska-Anyszka M. How to find the optimal partner--studies of snurportin 1 interactions with U snRNA 5' TMG-cap analogues containing modified 2-amino group of 7-methylguanosine. Bioorg Med Chem. 2015; 23(15): 4660-8. Zytek M, Kowalska J, Lukaszewicz M, Wojtczak BA, Zuberek J, Ferenc-Mrozek A, Darzynkiewicz E, Niedzwiecka A, Jemielity J. Towards novel efficient and stable nuclear import signals: synthesis and properties of trimethylguanosine cap analogs modified within the 5',5'-triphosphate bridge. Org Biomol Chem. 2014; 12(45): 9184-99. "
