Global

Oncology Experts

Nathan I

Principle Scientist
Oncology
Pfizer Oncology
Portugal

Biography

Dr. Ihle joined Pfizer in 2013 and began working to identify specific dependencies in cancer cells necessary for growth and survival. His current work focuses on efforts to inhibit Ras signaling, a pathway disregulated at a high frequency in tumors while sparing any detrimental effects of Ras inhibition in normal tissue. He his BS in Environmental Biology at the University of Arizona in 2001. Prior to joining Pfizer, he began working in the laboratory of Garth Powis characterizing PI3K inhibitors derived from the natural product Wortmannin. In 2005, the lab moved to MD Anderson in Houston, Texas where Dr. Ihle became a program coordinator for an optimized PI3K inhibitor, leading studies outlining how to mitigate the on-target hyperglycemia seen with PI3K inhibition and describing the interplay between activating KRas and PI3K mutations in determining the response of cancer cells. In 2008, this inhibitor moved to clinical trials and he began working towards his PhD, becoming a full time student in 2010. For his graduate work, Dr. Ihle provided basic research support to a multi-armed targeted therapy clinical trial studying KRas signaling in lung cancer. His work has contributed to 16 publications with nine being first author studies or reviews.

Research Interest

cancer cells, tumors, Environmental Biology, hyperglycemia, lung cancer, oncology

Global Experts from Portugal

Global Experts in Subject

Share This Profile
Recent Expert Updates
  • Matthew L Stone
    Matthew L Stone
    pediatrics
    University of Virginia Health System; Charlottesville, VA
    United States of America
  • Dr.   Matthew
    Dr. Matthew
    pediatrics
    University of Virginia Health System; Charlottesville, VA
    United States of America
  • Dr.  L Stone Matthew
    Dr. L Stone Matthew
    pediatrics
    University of Virginia Health System; Charlottesville, VA
    United States of America
  • Dr.  L Stone
    Dr. L Stone
    pediatrics
    University of Virginia Health System; Charlottesville, VA
    United States of America
  • Dr. Matthew L Stone
    Dr. Matthew L Stone
    pediatrics
    University of Virginia Health System; Charlottesville, VA
    United States of America
  • Dr.  R Sameh
    Dr. R Sameh
    pediatrics
    King Abdul Aziz University
    United Arab Emirates
  • Dr.   R Ismail,
    Dr. R Ismail,
    pediatrics
    King Abdul Aziz University
    United Arab Emirates
  • Sameh R Ismail,
    Sameh R Ismail,
    pediatrics
    King Abdul Aziz University
    United Arab Emirates
  • Dr.   Sameh R Ismail,
    Dr. Sameh R Ismail,
    pediatrics
    King Abdul Aziz University
    United Arab Emirates
  • Dr.   William
    Dr. William
    pediatrics
    Maimonides Medical Center
    United States of America