Edmundo N. Kraiselburd

Biography

Edmundo N. Kraiselburd  is working as a Professor in the department of General Pediatrics at University of Puerto Rico, Puerto Rico. His research interest includes: Evaluation Studies of a DNA Vaccine Expressing SIVsm VLP: The long term objective of this research is to develop a vaccine capable of inducing protective immune responses in rhesus macaques against pathogenic simian immunodeficiency virus (SIV). For this purpose, we are evaluating the immune responses generated in macaques by different SIV DNA vaccine candidates (Vec B7). The 1.6Kb deletion (pol,vif,vpr,and vpx) of SIVsm87 provirus DNA was introduced into the SIVsmH4 DNA to construct the Vec B7 expression vector. Vec B7 expressed SIVsm gag, env and nef proteins, produced virus-like particles (VLP) in vitro, and was immunogenic in mice. This project was supported by several grants , including R01 AI 44592 from NIH (NIAID). He is the author of many articles published in several reputed journals.  

Research Interest

Edmundo N. Kraiselburd’s research interest includes: Evaluation Studies of a DNA Vaccine Expressing SIVsm VLP: The long term objective of this research is to develop a vaccine capable of inducing protective immune responses in rhesus macaques against pathogenic simian immunodeficiency virus (SIV). For this purpose, we are evaluating the immune responses generated in macaques by different SIV DNA vaccine candidates (Vec B7). The 1.6Kb deletion (pol,vif,vpr,and vpx) of SIVsm87 provirus DNA was introduced into the SIVsmH4 DNA to construct the Vec B7 expression vector. Vec B7 expressed SIVsm gag, env and nef proteins, produced virus-like particles (VLP) in vitro, and was immunogenic in mice. This project was supported by several grants , including R01 AI 44592 from NIH (NIAID).