Prasanna R Kolatkar
Hamad bin Khalifa University
Prasanna R Kolatkar obtained his PhD from the University of Texas at Austin in Chemistry and Biochemistry. He then joined Michael G Rossmann's laboratory as a post-doctoral scientist at Purdue University where he was funded by a Jane Coffin Childs Post-doctoral Fellowship.
The combinatorial code for transcription factors (TFs) controlling cell fate. Using biochemical and biophysical methods I hope to find how different TFs combine to carry out diverse cell fates such as pluripotency and differentiation , especially towards B islet cell development.
Ralf Jauch, Irene Aksoy, Andrew Paul Hutchins, Calista Keow Leng Ng, Xian Feng Tian, Jiaxuan Chen, Paaventhan Palasingam, Paul Robson, Lawrence W. Stanton and Prasanna R Kolatkar. Conversion of Sox17 into a Pluripotency Reprogramming Factor by re-engine Stem Cells. 2011. Jun;29(6):940-51. 2011
Aksoy I, Jauch R, Chen J, Dyla M, Divakar U, Bogu GK, Teo R, Leng Ng CK, Herath W, Lili S, Hutchins AP, Robson P, Kolatkar PR*, Stanton LW. Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm. EMBO J. 2013. 32(7): 938-53.*co-corresponding author 2013
Aksoy, I., Jauch, R., Eras, V., Bin, A.C-W., Chen, J., Divakar, U., Ng, C. K-L., Kolatkar*, P.R., Stanton, L.W. Sox transcription factors require selective interactions with Oct4 and specific transactivation functions to mediate reprogramming. Stem Cells. 2013. Dec;31(12):2632-46.*co-corresponding author 2013