Sergei V. Benevolensky
Head of Laboratory
LABORATORY OF GENE EXPRESSION OPTIMIZATION
AN Bach Institute of Biochemistry
Russian Federation
Biography
Saccharomyces cerevisiae strain was constructed producing secreted correctly folded human mechano growth factor (hMGF). Proteinase was identified degrading hMGF in wild type strains. Production of humanized antibody fragments in yeast expression system was achieved. Genetic system responsible for catabolite repression in fungi Penicillium canescens is discovered. Genetic system of multiple endoxylanases in Penicillium canescens is described. Producer strain for recombinant laccase Тrametes sp. is constructed.
Research Interest
Homo- and heterologous gene expression in yeast. Analysis of genetic factors implicated in heterologous secretion efficiency. Construction of strains producing foreign proteins. Regulation of gene expression coding for secreted proteins in Penicillium canescens.
