Ruben Abagyan
Professor
Pharmaceutical
Skagit Valley Hospital
Russian Federation
Biography
Dr. Abagyan’s research focuses on the development of novel technologies for structure based drug discovery and optimization, structural systems biology for target finding and protein modeling. We screen specific biomedical targets to discover new drug leads, and validate them experimentally. The applications include antibiotics, cancer, neuro-degeneration, viral and endocrine diseases. To extend the reach of docking we model alternative functional states and allosteric pockets of the kinases, GPCRs and Nuclear Receptors. We derived comprehensive sets of ligand pockets (the Pocketome) competing for ligands and metabolites in different organisms. These data are used for target identification and polypharmacology profiling. We dock drugs, leads and environmental chemicals to the ‘anti-target’ models to predict endocrine disruption and other adverse effects.
Research Interest
Structure Based Drug Discovery, Toxicology, Protein Modeling and Design
