Yuri Kotelevtsev
Professor and Associate Director
Translational Biomedicine
Skoltech
Russian Federation
Biography
Yuri Kotelevtsev’s main expertise is in molecular genetics of cardiovascular disease and in gene targeting in embryonic stem cells. He has provided a crucial contribution towards the discovery of the first genetic linkage between elevated blood pressure and angiotensinogen in essential hypertension in men. He has also introduced several knockout and transgenic models of hypertension, metabolic syndrome and atherosclerosis, including knock out (KO) of 11 β−hydroxysteroid dehydrogenase type I (11β-HSD-1) gene. Resistance of 11β-HSD-1 knockout mice to obesity and stress established this gene as a drug target (see publication # 41 in the Publications tab). This publication initiated drug discovery programmes in the leading pharmaceutical companies. Now the inhibitors of 11β-HSD-1 are in clinical trials for treatment of obesity, metabolic syndrome and dimentia. Genetic KO of 11β-HSD-2 produced a model of hypokalemia and hypertension.
Research Interest
molecular and cellular mechanisms of hypertension and atherosclerosis transgenic models of cardiovascular disease genetically modified mice as a platform for drug discovery
