Yury Kostyukevich

Biography

Yury completed his postgraduate studies in Chemical Physics at the Moscow Institute for Physics and Technology defending his thesis at the Semenov Institute of Chemical Physics of Russian Academy of Sciences. He developed a novel ion trap for the ion cyclotron resonance mass spectrometer. The patent for the invention is owned by Bruker Corporation. He developed a simple method for structural investigation of biomolecules based on gas phase ion-molecular reactions combined with ultrahigh resolution mass spectrometry. He discovered the presence of multiple gas-phase conformations of oligosaccharides ions. He made a considerable contribution to the investigation of structure of individual molecules of natural organic matter (oil, humic substances). Yury Kostyukevich participated in many proteomics projects including investigation of proteome of urine and exhaled breath condensate. He was an exchange student in the Laboratory of Organic Chemistry in ETH, Zurich and visited many universities. Publications: Kostyukevich Y., Kononikhin A., Zherebker A., Popov I., Perminova I., Nikolaev E. Enumeration of non-labile oxygen atoms in dissolved organic matter by use of 16O/18O exchange and Fourier transform ion-cyclotron resonance mass spectrometry // Analytical and Bioanalytical Chemistry – 2014 – DOI 10.1007/s00216-014-8097-9. (IF = 3.6) Perminova I.,  Dubinenkov I., Kononikhin A., Konstantinov A., Zherebker A., Andzhushev M., Lebedev V., Bulygina E., Holmes R.,Kostyukevich Y., Popov I., Nikolaev E. Molecular Mapping of Sorbent Selectivities with Respect to Isolation of Arctic Dissolved Organic Matter as Measured by Fourier Transform Mass Spectrometry // Environmental Science & Technology – 2014. – V.48. – N.13. – P.7461-7468DOI: 10.1021/es5015423 (IF=5.2) Kostyukevich Y., Kononikhin A., Popov I., Starodubtzeva N., Kukaev E., Nikolaev E. Letter: Separation of tautomeric forms of [2-Nitrophloroglucinol-H]- by in-ESI source Hydrogen/deuterium exchange approach. // European Journal of Mass Spectrometry – 2014. – doi: 10.1255/ejms.1282 (IF=1.1) Popov I., Nagornov K., Vladimirov G.,Kostyukevich Y., Nikolaev E. Twelve Million Resolving Power on 4.7 T Fourier Transform Ion Cyclotron Resonance Instrument with Dynamically Harmonized Cell—Observation of Fine Structure in Peptide Mass Spectra // Journal of the American Society for Mass Spectrometry. – 2014. – V. 25. – N. 5. – P. 790-799. (IF=4.0) Nikolaev E.,Kostyukevich Y., Vladimirov G. Fourier transform ion cyclotron resonance (FT ICR) mass spectrometry: Theory and simulations // Mass Spectrometry Reviews. – 2014. – Early View. (IF=7.7) Kostyukevich Y., Kononikhin A., Popov I., Nikolaev E. In-ESI source Hydrogen/Deuterium exchange of carbohydrates ions // Analytical Chemistry. – 2014. – V. 86. – N. 15. – P. 2595-2600. (IF=5.7) Kostyukevich Y., Kononikhin A., Popov I., Kharybin O., Perminova I., Konstantinov A., Nikolaev E. Enumeration of labile hydrogens in natural organic matter using hydrogen/deuterium exchange Fourier Transform Ion Cyclotron Resonance mass spectrometry // Analytical Chemistry. – 2013. – V. 85. – N. 22. – P. 11007-11013. (IF=5.7) Popov I., Starodubtseva N., Indeikina M.,Kostyukevich Y., Kononikhin A.,  Nikolaeva M., Kukaev E., Kozin, S., Makarov A., Nikolaev E. Mass spectrometric identification of posttranslational modifications in transthyretin from human blood // MOLECULAR BIOLOGY. – 2013. – V.47 – N. 6 – P. 885-893. (IF=0.8) Kononikhin A., Huang M., Popov I.,Kostyukevich Y., Kukaev E., Boldyrev A., Spasskiy A., Leypunskiy I., Shiea J., Nikolaev E. Signal enhancement in electrospray laser desorption/ionization mass spectrometry by using a black oxide-coated metal target and a relatively low laser fluence // European Journal of Mass Spectrometry. – 2013. – V.19. – N. 4. – P. 247-252. (IF=1.1) Kostyukevich Y., Kononikhin A., Popov I., Nikolaev E. Simple Atmospheric Hydrogen/Deuterium Exchange Method for Enumeration of Labile Hydrogens by Electrospray Ionization Mass Spectrometry // Analytical Chemistry. – 2013. – V. 85. – N. 11. – P. 5330-5334 (IF=5.7) Kostyukevich Y., Vladimirov G., Nikolaev E. Dynamically Harmonized FT-ICR Cell with Specially Shaped Electrodes for Compensation of Inhomogeneity of the Magnetic Field. Computer Simulations of the Electric Field and Ion Motion Dynamics // Journal of the American Society for Mass Spectrometry. – 2012. – V. 23. – N. 12. – P. 2198-2207. (IF=4.0) Kostyukevich Y., Umanskii S. Dependence of the molecular iodine B-state predissociation induced by a femtosecond laser pulse on pulse phase modulation // Quantum Electronics. –  2011. – V.41 – N.12 – P.1104-1108. (IF=0.8) Patents: Nikolaev E.,Kostyukevich Y., Vladimirov G. EP Patent No. 2706557 A2 (11 Sep 2012). Kostyukevich Y., Vladimirov G., Nikolaev E. US Patent No. 20140070090 A1 (11 Sep 2012).

Research Interest

Application of mass-spectrometers for near-Earth space research including development of novel instrumentation (ion funnels, vacuum chambers etc.)