George Kulik
Associate Professor
Life Sciences
Alfaisal University
Saudi Arabia
Biography
Dr. George Kulik earned his graduate degree at the Institute of Experimental Pathology in Kiev, Ukraine and obtained post-doctoral training in the Imperial Cancer Research Fund (London, UK) and University of Virginia (Charlottesville, USA). As a post-doctoral fellow Dr. Kulik identified the critical role of the PI3K/AKT signaling module in apoptosis inhibition by IGF-1. The importance of PI3K/AKT signaling for cell survival was later confirmed in numerous publications and now this signaling pathway is a major focus of leading pharmaceutical companies. He then moved to Wake Forest University School of Medicine where his laboratory investigated the mechanisms by which cancer cell signaling pathways become integrated into a robust regulatory network, and the ways this knowledge can be utilized to improve cancer diagnosis and therapy. Research by Dr. Kulik group provides insight into the linkage between emotional stress and the regulation of anti-apoptotic pathways in tumors.
Research Interest
Life Sciences
Publications
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Konduru S. R. Sastry, Yelena Karpova, and George Kulik *. (2006) Epidermal Growth Factor Protects Prostat e Cancer Cells from Apoptosis by Inducing BAD Phosphorylation via Redundant Signaling Pathways. J Biol. Chem. 281(37):27367 - 77
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Konduru S. R. Sastry, Adrienne Joy Smith, Yelena Karpova, Sandeep Robert Datta, and George Kulik *. (2006) Diverse anti - apoptotic signaling pathways activated by VIP, EGF and PI3K in prostate cancer cells conv erge on BAD. J Biol Chem. 281(30):20891 - 901.
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Jonathan P. Carson , Marcelina Behnam, Jennifer Sutton, Chunying Du , Xiaodong Wang, Donald Hunt, Michael J. Weber and George Kulik*. (2002) Smac is required for cytochrome c - induced apoptosis in prostate cancer LNCaP cells. Cancer Res. 62: 18 - 23.
