Mateen Ahmad Khan
Assistant Professor
Biology
Alfaisal University
Saudi Arabia
Biography
Dr. Mateen A. Khan obtained his PhD degree in the field of Biotechnology from the A. M. University and postdoctoral training in the City University of New York, and Stanford University, California, USA. He has published 22 peer reviewed journal articles in a high impact journals including PNAS, NAR, J. Biol. Chem. and Biochemistry ACS. He has published 2 books. He has been identified as one of the best young scientist at the City University of New York by Gene Centre foundation and his name has been published by News Review. Dr. Khan's research achievements has been identified by the faculty of 1000 biology scientist. His specialization is in the field of gene regulation of protein biosynthesis and iron metabolism. Dr. Khan is working in a collaboration with Dr. Goss at Hunter College of the City University of New York, USA. Dr. Khan research interests are directed toward understanding the mechanism of gene regulation of protein biosynthesis and iron metabolism using biotechnology, biochemistry, molecular biology and biophysical techniques. Iron deficiency and overload are both major public health problems throughout the world. About 2.15 billion people in the world and 21% of the population in the Kingdom of Saudi Arabia are suffering from iron related diseases. Dr. Khan interest in understanding how regulation of gene expression via Iron Regulatory Protein and Iron Responsive Element-mRNA interactions contributes to an organism ability to respond to dietary iron, alterations in iron metabolism due to host/pathogen interaction and to changes in iron metabolism which occur during development, differentiation and disease. Maintaining the proper amount of iron is a challenge for everyone. Therefore, the studies on iron regulation will have useful outcome for the human population suffering from iron diseases.
Research Interest
Interested in understanding how regulation of gene expression via IRP/IRE interactions contributes to an organism ability to respond t o dietary iron, alterations in iron metabolism due to host/pathogen interaction and to changes in iron metabolism which occur during development, differentiation and disease.
Publications
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Khan, M.A. and Goss, D.J. (2012) Poly(A) - binding protein increases the binding affinity and kin etic rates of viral protein linked to genome (VPg) interaction with translation initiation factors eIFiso4F and eIFiso4F - 4B complex. Biochemistry 51(7), 1388 - 95.
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Ma, J ., Haldar, S., Khan, M.A., Sharma, S., Merrick, W.C., Theil, E.C., and Goss, D.J. (2012). Fe2+/IRE - RNA interactions have opposite effects on eIF 4F and IRP protein/mRNA binding for metal - metabolite control of protein synthesis. Proceedings of the National Academy of Sciences (PNAS) USA 109(22) 8417 - 8422.
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Khan, M.A ., Ma, J., Walden W. E., Merrick, W.C., Theil, E.C., and Goss D.J. (2014). Rapid Kinetics of Iron Responsive Element (IRE) RNA/Iron Regulatory Protei n1 and IRE - RNA/eIF4F Complexes Respond Differently to Metal Ions. Nucleic Acid Research , 42(10) 6567 - 6577
