Biological and Environmental Science and Engineering Division
King Abdullah University Of Science and Technology
The epigenome constitutes the chromosomal molecular interface that allows the genome to interact with the environment. The epigenome enables cells to learn, remember and maintain their functional states throughout life and enable organisms to integrate environmental signals. Prof. Orlando's lab is interested in investigating the chromatin mediated fundamental mechanisms that control cell identity and plasticity. These include signaling to chromatin regulation and nuclear organization by Polycomb proteins, the role of ncRNA-protein interactions in transcriptional regulation, Epigenomics and how this relates for development, transdifferentiation and adaptation (e.g. Metabolism), in particular in stress conditions. Furthermore, as part of the mechanistic plastic properties of the genome in response to developmental and environmental cues, Prof. Orlando's lab also investigates the epigenetic regulation of the expression and dynamics of transposable elements and their role in cell differentiation and epigenomic biodiversity.
Prof. Orlando's lab is interested in investigating the chromatin mediated fundamental mechanisms that control cell identity and plasticity.