Wang, Hongyan
Associate Professor and Deputy Director
Neuroscience & Behavioural Disorders
Duke-NUS Graduate Medical School
Singapore
Biography
Dr. Wang is a recipient of Singapore National Academy of Science Young Scientist Award (2008) and National Research Foundation (NRF) Research Fellowship (2009-2014). The choice of self-renewal versus differentiation is a fundamental issue in stem cell and cancer biology. Recently, Drosophila melanogaster neural stem cells, larval brain neuroblasts, were emerged as an excellent model for study stem cell self-renewal and tumorigenesis.
Research Interest
Brain tumor suppressors and underlying mechanisms by which they prevent tumor formation in larval brains.Currently She is interested in addressing the following key questions: What mutations trigger neural stem cells to become cancer stem cells? How asymmetric divisions of neural stem cells are regulated?
Publications
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Zhang Y, Rai M, Wang C, Cayetano Gonzalez and Wang H. Prefoldin and Pins synergistically regulate asymmetric division and suppress dedifferentiation. Scientific Reports (2016). March 30.
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Li S, Koe CT, Tay ST, Tan ALL, Zhang S, Zhang Y, Tan P, Sung WK and Wang H. An Intrinsic Mechanism Controls Reactivation of Neural Stem Cells by Spindle Matrix Proteins. Nature Communications (2017). Jul 25;8(1):122. doi: 10.1038/s41467-017-00172-9. (Press release by Duke-NUS).
