Jonathan Goke
Senior Research Scientist
research and development
Genome Institute of Singapore
Singapore
Biography
Even though all cells of the human body essentially share the same genetic information, the cell types that form the organs and tissues appear very diverse and have distinct properties. The central question of our research is what determines the identity of mammalian cells during development and differentiation; and how cellular identity is impaired in disease. We investigate transcript diversity, alternative splicing, gene regulation, and epigenetics to identify key elements and mechanisms involved in maintenance and conversion of cellular identities. Using machine learning techniques, we study the role of DNA sequence in regulation of cell-type specific expression signatures. We are closely collaborating with wet labs to translate computational models to cellular phenotypes. PhD projects available starting in August 2017. Highly motivated students with a background in bioinformatics, statistics or computer science are welcome to contact Jonathan Göke.
Research Interest
Business Administration, Biotechnology, Molecular Biology, genome
