Maya Mellisa Makatini
Associate Professor
Chemistry
University of the Witwatersrand
South Africa
Biography
Maya Mellisa Makatini is currently working as Associate Professor of chemistry at University of Witwatersrand
Research Interest
current research focus is in the field of synthetic peptides, mainly in the following topics: The design and synthesis of wound healing and antimicrobial peptides and peptidomimetics. The design and synthesis of organic compounds and peptides targeting plant, animal and human diseases. The synthesis of peptides, peptoids and peptidomimetics that can be used in diagnostics. Determination of organic compounds and peptides’s 3-D structures using NMR (ROESY/NOESY). Chromatography: Characterization and purification using LCMS and Prep-HPLC respectively of peptides.
Publications
-
Makatini MM, Petzold K, Sriharsha SN, Ndlovu N, Soliman MES et al. (2011) Synthesis and structural studies of pentacycloundecane-based HIV-1 PR inhibitors: A hybrid 2D NMR and docking/QM/MM/MD approach. European Journal of Medicinal Chemistry.
-
Makatini MM, Petzold K, Alves CN, Arvidsson PI, Honarparvar B et al.(2012) Synthesis, screening and computational investigation of pentacycloundecane-peptoids as potent CSA-HIV PR inhibitors. European Journal of Medicinal Chemistry 57: 459-467.
-
Makatini MM, Petzold K, Alves CN, Arvidsson PI, Honarparvar B et al.(2013) Synthesis, 2D-NMR and molecular modeling studies of pentacycloundecane lactam-peptides and peptoids as potential HIV-1 wild type C-SA protease inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 28: 78-88.
