Diego M. A. Guérin
Researcher
Biophysics
Biofisika Basque Centre for Biophysics
Spain
Biography
Diego M. A. Guérin earned his Ms and PhD in Physics from the National University of La Plata, Argentina. He did a postdoctoral research stage (1986-87) at the Purdue University working on Rhinovirus structure with M. Rossmann, and then at the Institute Pasteur, in Paris, to work on the modellization of Poliovirus epitopes with R. Poljak. Dr. Guérin was visiting researcher at the NIH-NCI Frederick Cancer Research & Development Center, US, (1993), at the Institute Pasteur (1997-1998), and at Instituto de Biología Molecular de Barcelona (2001.2002).
Research Interest
His research lines have been focused on several aspect of virus: i) to unravel non-enveloped capsid assembly and disassembly using Triatoma virus (TrV) as model; ii) the potential use of TrV as control agent of Chagas disease vectors, and iii) the TrV-VLPs as carrier of pathogen’s epitopes in the development of chimeric vaccines against parasitic diseases.
Publications
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Squires G, Pous J, Agirre J, Rozas-Dennis GS, Costabel MD, Marti GA, Navaza J, Bressanelli S, Guérin DM, Rey FA. Structure of the Triatoma virus capsid. Acta Crystallographica Section D: Biological Crystallography. 2013 Jun 1;69(6):1026-37.
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Marti GA, EcheverrÃa MG, Susevich ML, Ceccarelli S, Balsalobre A, Rabinovich JE, Diotaiuti L, Guérin DM. Exploration for Triatoma virus (TrV) infection in laboratory-reared triatomines of Latin America: a collaborative study. International Journal of Tropical Insect Science. 2013 Dec;33(4):294-304.
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Sánchez-Magraner L, Posada IM, Andraka N, Contreras FX, Viguera AR, Guérin DM, Arrondo JL, Monaco HL, Goñi FM. The C-terminal transmembrane domain of human phospholipid scramblase 1 is essential for the protein flip-flop activity and Ca2+-binding. The Journal of membrane biology. 2014 Feb 1;247(2):155-65.
