Hartmut Luecke
Research Professor
Biologist
Biofisika Basque Centre for Biophysics
Spain
Biography
Hartmut “Hudel” Luecke (born in Göttingen, Germany) is a structural biologist with an emphasis on membrane proteins and structure-based drug discovery. He received his B.S. from Heidelberg University (Physics, Chemistry & Computer Science), his Ph.D. from Rice University in 1990 (Macromolecular Crystallography) and performed postdoctoral work with Robert Huber at the Max-Planck-Institute for Biochemistry in Martinsried. He spent the next three years at the Stanford Synchrotron as a Structural Biologist before joining the faculty at the University of California, Irvine. in 1996, where he is Professor of Biochemistry, Biophysics and Computer Science. He is also the founding director of the UC Irvine Center for Biomembrane Systems
Research Interest
Protein crystallography Structure function studies Membrane proteins Bacteriorhodopsin Annexin G protein-coupled receptors (GPCR) Structure-based drug design
Publications
-
Wallentine BD, Wang Y, Tretyachenko-Ladokhina V, Tan M, Senear DF, Luecke H. Structures of oncogenic, suppressor and rescued p53 core-domain variants: mechanisms of mutant p53 rescue. Acta Crystallographica Section D: Biological Crystallography. 2013 Oct 1;69(10):2146-56.
-
Ran T, Ozorowski G, Gao Y, Sineshchekov OA, Wang W, Spudich JL, Luecke H. Cross-protomer interaction with the photoactive site in oligomeric proteorhodopsin complexes. Acta Crystallographica Section D: Biological Crystallography. 2013 Oct 1;69(10):1965-80.
-
Kryshtafovych A, Moult J, Bales P, Bazan JF, Biasini M, Burgin A, Chen C, Cochran FV, Craig TK, Das R, Fass D. Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th Critical Assessment of Techniques for Protein Structure Prediction Experiment CASP10. Proteins: Structure, Function, and Bioinformatics. 2014 Feb 1;82(S2):26-42.
