Erwin Carlos Knecht Roberto
TEAM LEADER
Molecular Basis of Human Pathologies
Centro de Investigacion Principe Felipe
Spain
Biography
Current position is team leader of Cell and Developmental Biology Centro de Investigacion Principe Felipe Valencia, Spain
Research Interest
Interested in two research areas: i) the regulation of the major intracellular protein degradation mechanisms (autophagy and the ubiquitin-proteasome system), and ii) the relevance of their alterations in various rare diseases.
Publications
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PTEN increases autophagy and inhibits the ubiquitin-proteasome pathway in glioma cells independently of its lipid phosphatase activity.
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Glucose induces autophagy under starvation conditions by a p38 MAPK-dependent pathway.
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Oxidative stress regulates the ubiquitin-proteasome system and immunoproteasome functioning in a mouse model of X-adrenoleukodystrophy.
