Mar Orzáez Calatayud
TEAM LEADER
Advanced Therapies
Centro de Investigacion Principe Felipe
Spain
Biography
PhD at the Biochemistry Department (University of Valencia) on the membrane protein folding field. - Postdoctoral with ten years of research experience developing modulators of protein-protein interactions relevant for the control of apoptosis and inflammation disorders. Extensive experience in developing in vitro assays, cellular and animal models of diseases.
Research Interest
Apoptosis, Proteins, Cell Death, Kinase, Bcl-2, Signaling Pathways, Mitochondria, Cell Culture, Cell Signaling, Cancer Biology, Cell Proliferation, Molecular Cell Biology, Cancer Cell Biology
Publications
-
Altered mitochondria morphology and cell metabolism in Apaf1-deficient cells.
-
Inactivation of Apaf1 reduces the formation of mutant huntingtin-dependent aggregates and cell death.
-
Peptides derived from the transmembrane domain of Bcl-2 proteins as potential mitochondrial priming tools.
-
Caspase 3 Targeted Cargo Delivery in Apoptotic Cells Using Capped Mesoporous Silica Nanoparticles.
