José Portugal
Senior Research Scientist
General Science
ENTRECHEM
Spain
Biography
José Portugal is Senior Research Scientist at the IBMB-CSIC in Barcelona, Spain. His research, focused on the interactions between antitumor drugs and DNA, seeks to examine the molecular and cellular bases of specific recognition. José Portugal received his PhD in Biology from the University of Barcelona, Spain in 1983. He was a post-doc at the University of Cambridge, UK (1985-87), and he was appointed Lecturer in Biochemistry at the University of Barcelona (1987-1992). From 1992, he is a member of the Institute of Molecular Biology-CSIC in Barcelona. His work aims at understanding the mechanisms used by DNA-binding drugs to inhibit transcription both in vitro and in vivo, and how changes in the transcriptome of cancer cells commit them to die. To this end, he analyzes the sequence-specific DNA binding of new antitumor drugs, including the effects of mithramycin analogues, on DNA-protein interactions during the transcription of oncogenes and tumor suppressors.
Research Interest
General Science
