Nuria Izquierdo-useros
Associate researcher
Retrovirology and Clinical Studies (GREC)
Spain
Biography
Nuria Izquierdo-Useros is a biologist from Madrid who obtained her PhD from the Autonomous University of Barcelona (UAB) in 2009. Her research focuses on the interplay between dendritic cells and HIV-1 and includes studies of the molecular mechanisms for viral capture and endocytosis associated with an exosome pathway that is exploited by retroviruses to evade the host immune system. In 2012, she contributed to the identification of Siglec-1 as a novel dendritic cell receptor that mediates HIV-1 capture via recognition of specific gangliosides exposed on viral and exosomal membranes. She pursued post-doctoral studies — funded by the José Castillejo fellowship programme — with Prof. Dr. Hans-Georg Kräusslich at Heidelberg University (Germany) and was awarded a Mathilde Krim Fellowship in Biomedical Research —funded by amfAR—. She has collaborated actively with other groups in the same field and has made several stays at foreign research centres, including Boston University School of Medicine (USA) and the Centre Hospitalier Universitaire Vaudois (Switzerland). She has been employed as an associate researcher at IrsiCaixa since 2016, where she continues her work on antigen-presenting cells and viral pathogenesis, with a particular focus on the design of novel antiviral tools.
Research Interest
Virology, Immunology, HIV, Pathogenesis.
Publications
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Izquierdo-Useros, N., Naranjo-Gómez, M., Archer, J., Hatch, S. C., Erkizia, I., Blanco, J., … Martinez-Picado, J. (2009). Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway. Blood, 113(12), 2732–2741.
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Izquierdo-Useros, N., Lorizate, M., Contreras, F.-X., Rodriguez-Plata, M. T., Glass, B., Erkizia, I., … Martinez-Picado, J. (2012). Sialyllactose in Viral Membrane Gangliosides Is a Novel Molecular Recognition Pattern for Mature Dendritic Cell Capture of HIV-1. PLoS Biology, 10(4), e1001315.
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Izquierdo-Useros, N., Lorizate, M., Puertas, M. C., Rodriguez-Plata, M. T., Zangger, N., Erikson, E., … Martinez-Picado, J. (2012). Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans-Infection Through Recognition of Viral Membrane Gangliosides. PLoS Biology, 10(12), e1001448.
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Izquierdo-Useros, N., Lorizate, M., McLaren, P. J., Telenti, A., Kräusslich, H.-G., & Martinez-Picado, J. (2014). HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1. PLoS Pathogens, 10(7), e1004146.
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Pino, M., Erkizia, I., Benet, S., Erikson, E., Fernández-Figueras, M. T., Guerrero, D., … Izquierdo-Useros, N. (2015). HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells. Retrovirology, 12, 37.
