Arribas LÓpez, JoaquÃn Vicente
Research Professor
biochemistry
Institucio Catalana de Recerca i Estudis Avancats
Spain
Biography
Joaquín Arribas completed his undergraduate studies in biochemistry at the Universidad Autónoma de Madrid in 1987. At the same university he subsequently worked on the regulation of the catalytic activities of the proteasome and received his PhD in Biology in 1991. Sponsored by a fellowship from the Spanish Ministry of Education and Science, he joined the Memorial Sloan-Kettering Cancer Center, New York (USA), as a Postdoctoral Fellow to work with J. Massagué (1992-1996) on the proteolytic processing of transmembrane growth factors. In 1997 he joined the oncology department at Hospital Vall d'Hebron in Barcelona as a Staff Scientist, since then he has lead the research group on Growth Factors. Since 2010 he has served as Director of VHIO´s Preclinical Research Program. His research has been recognized through an EMBO Young Investigator Programme (YIP) Award and the Beckman Coulter Award for the Best Young Spanish Investigator in Biochemistry and Molecular Biology.
Research Interest
Determine the therapeutic value of the anti-p95HER2 antibodies to treat breast cancers. Analyze cellular heterogeneity of HER2-positive breast tumors. Explore the link between HER2-driven senescence and breast cancer invasion.
Publications
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Morancho, B., MartÃnez-Barriocanal, A., Villanueva, J. and Arribas, J. (2015) Ectodomain shedding controls non-cell autonomous effects of oncogene-induced senescence. Breast Cancer Res 17, 106.
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Nuciforo, P., Thyparambil, S., Aura, C., Garrido-Castro, A., Marta Vilaro, M., Peg, V., Jimenez, J., Hoos, W., Burrows, J., Todd Hembrough, T., Ferreres, J. C., Perez-Garcia, J., Arribas, J., Cortes, J., and Scaltriti, M. (2015) High HER2 protein levels measured by multiplex mass spectrometry correlate with increased overall survival in patients treated with anti-HER2 therapy. Molecular Oncology Sep 15. pii: S1574-7891(15)00161-1.
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Zacarias-Fluck, M., Morancho, B., Vicario, R., Luque-GarcÃa, A., Ferrer-Ramón, C., Escorihuela, M., Villanueva, J., Rubio, I. & Arribas, J. (2015) Cellular senescence promotes the growth of HER2-positive breast cancers through IL-6 signaling. J Natl Cancer Inst 107 (5): djv020
