Cerutti, Andrea
Research Professor
Life & Medical Sciences
Institucio Catalana de Recerca i Estudis Avancats
Spain
Biography
Andrea Cerutti, MD, is an ICREA Research Professor since 2010 and leads the B Cell Biology Group at PRBB-IMIM. He serves as reviewer for the European Research Council, the National Institutes of Health and several biomedical and immunology journals, including Science, Nature, Immunity, Nature Immunology, Nature Medicine, Nature Communications, The Journal of Experimental Medicine and The Journal of Immunology. He is a member of The American Society for Clinical Investigation and The Henry Kunkel Society, as well as Associate Editor of Mucosal Immunology. He organized two Keystone Symposium meetings on B cells and published over 100 research articles in top-ranked immunology journals and lectures in international meetings as well as American and European universities.
Research Interest
His group studies the cellular and signaling networks underlying immunoglobulin (Ig) heavy chain class switching and V(D)J gene somatic hypermutation, two B cell-mediated processes essential for the generation of immune diversity and protection. They are particularly interested in the mechanisms by which the innate immune system interacts with B cells and in the strategies utilized by pathogens to evade Ig production systemically and at mucosal sites of entry. Their research is relevant to infections, inflammation, autoimmunity, immunodeficiencies and vaccine development.
Publications
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Chorny A, Cerutti A. CEACAM1-S: the virtues of alternative splicing in gut immunity. Immunity 2012, 37:768-770 (IF: 19.3).
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Almejun MB, Cols M, Zelazko M, Oleastro M, Cerutti A, Oppezzo P, Cunningham-Rundles C, Danielian S. Naturally occurring mutation affecting the MyD88-binding site of TNFRSF13B impairs triggering of class switch recombination. European Journal of Immunology 2012, doi: 10.1002/eji.201242945 (IF: 5.103).
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Cerutti A, Cols M, Puga I. Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes. Nature Review Immunology 2013, 13:118-132 (IF: 28.3).
