Christou, Paul
Research Professor
Life & Medical Sciences
Institucio Catalana de Recerca i Estudis Avancats
Spain
Biography
Received BS degree in Chemistry and PhD in plant biochemistry from University College London. Worked as senior scientist at Agracetus Inc., Madison, WI, USA. Subsequently head of Molecular Biotechnology Unit, John Innes Centre, Norwich, UK, and then head of Crop Genetics and Biotechnology Department at the Fraunhofer Institute for Molecular Biotechnology and Applied Ecology, Aachen/Schmallenberg, Germany. Currently at Universitat de Lleida as an ICREA Research Professor and head of the Applied Plant Biotechnology Laboratory. Director Agrotecnio CERCA Center, Lleida 2013-2015
Research Interest
For the past several years they have been investigating the organization of foreign genes in important crops such as maize, rice and wheat and its impact on transgene expression levels and stability. Applied aspects of our research include production of high value recombinant pharmaceuticals (vaccines and antibodies) in plants for use in human health and veterinary medicine; engineering crop plants for enhanced nutrition and novel strategies of sustainable and environmentally friendly agriculture using transgenic approaches, all with emphasis on developing countries, poverty alleviation and food security. A recent major focus in the laboratory is plant synthetic biology and genome editing. Their group is heavily involved in training and capacity building in the area of plant biotechnology focusing on developing countries. More recently we have been focusing on multigene, multipathway engineering in plants and the development of tools and methodology for the application of synthetic biology to major crop plants.
Publications
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E. Arcalis, S. Marcel, F. Altmann, G. Drakakaki, R. Fischer, P. Christou and E. Stoger. Unexpected deposition patterns of recombinant proteins in post-ER compartments of wheat endosperm. Plant Physiol. (in press)
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E. Stoger, M. Sack, L. Nicholson, R. Fischer and P. Christou Recent progress in plantibody technology. Journal of Current Pharmaceutical Design (in press)
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L. Nicholson, P. Gonzalez-Melendi, C. van Dolleweerd, H Tuck, Y. Perrin, J. K-C Ma, R Fischer, P Christou and E. Stoger A recombinant multimeric immunoglobulin expressed in rice shows assembly-dependent subcellular localization in endosperm cells Plant Biotech J. (in press)