GonzÁlez HernÁndez, Cayetano

Biography

After completing a PhD on fly genetics in the laboratory of Pedro Ripoll at the Centre for Molecular Biology (CBM, Madrid, Spain), Cayetano González moved to David Glover's lab in the UK, first at Imperial College and later as a CRC Joint Principal Investigator at Dundee. In 1994, he took his first independent position, as a Group Leader at EMBL (Heidelberg, Germany). After the customary nine-year period at EMBL, he moved to the Centro Nacional de Investigaciones Oncológicas (CNIO, Madrid, Spain). In 2004 he moved to his present post at the Institute for Research in Biomedicine (IRB Barcelona) where he leads the Cell Division Group.

Research Interest

They model cancer in flies to understand the cellular changes that drive malignant growth and to identify conserved mechanisms that might be relevant for human cancer therapy. They focus on the mechanisms of malignant transformation in larval brains where they have found that neuroblasts can originate tumors if the process of self-renewing asymmetric division is disrupted, and that some tumor types are driven by the ectopic expression of germline proteins. They work on the mechanisms that bring about genome instability in Drosophila tumors and try establishing the actual extent to which such lesions contribute to tumor progression. They develop and make extensive use of microscopy techniques. They demonstrated that the microtubule cytoskeleton of Drosophila neuroblasts is governed by the distinct behaviour displayed by centrosomes in these cells. They maintain an active line of research to identify new centrosomal proteins and found some with human orthologs that are linked to human pathologies.