Llovet Bayer, Josep M
Research Professor
Life & Medical Sciences
Institucio Catalana de Recerca i Estudis Avancats
Spain
Biography
Josep M. Llovet, MD is ICREA Research Professor, BCLC Group, Liver Unit, IDIBAPS, Hospital Clinic, Univ. of Barcelona, Prof. of Medicine and Director of the Liver Cancer Program at the Icahn Mount Sinai School of Medicine, NY. He has published 242 manuscripts in HCC, including NEJM, Lancet, Nature, Nat. Genetics, Cancer Cell and Gastroenterology (IF: 3262;citations: 44.256;h-index: 85). Top 1% most cited researcher globally, Thomson Reuters 2014, 2015, 2016, Educational Councilor (2013-15), President of the ILCA (2011-13), Senior Editor of CCR, he has lectured in 500 international meetings and has been the PI of European grants FP7-HEPTROMIC,HEP-CAR,NIH-NIDDK R01-award, I+D grants and competitive private grants. His achievements are: 1. Establish a clinical and molecular classification for HCC. 2. Establish efficacy of chemoembolization and sorafenib for HCC. 3. Identification of novel drivers and activated pathways in HCC and ICC.
Research Interest
Prof Josep M. Llovet has been working in clinical and translational research in hepatocellular carcinoma (HCC) and cholangiocarcinoma (ICC) for the last 20 years .He is leading international randomized trials in HCC on novel targeted therapies and developing a molecular classification of the disease,understanding the genetic aberrations and signaling pathways involved and in the identification of new molecular targeted therapies. He has organized the HCC Genomic Consortium and the HEPTROMIC Consortium (funded by an FP-7 Grant) that includes several international HCC research centers: IDIBAPS-Hospital Clínic (Barcelona), Ichan Scool of Medicine at Mount Sinai (New York), INSERM (Paris), Univ. Tuebingen (Germany), Dana-Farber-MIT-Broad Institute (Boston) and NCI (Milan).The main future areas of interest are a) identify biomarkers predicting response to sorafenib or mechanisms of resistance b) translate oncogenic drivers discoveries as targeted therapies in HCC and ICC.
Publications
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Pinyol R, Llovet JM. Hepatocellular Carcinoma. Genome-scale metabolic models for hepatocellular carcinoma. Nat Rev Gastro & Hepatol 2014;11:336-337
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Llovet JM, Johnson PJ. Reply to X. Qi et al “ Brivanib for Hepatocellular Carcinoma Trials: Selection Bias From Barcelona Clinic Liver Cancer Stage?â€. Journal of Clinical Oncology 2014;32;968-969
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Pinyol. R, Tovar. V, Llovet JM. TERT promoter mutations: gatekeeper and driver of hepatocellular carcinoma. J Hepatol 2014;61:685-7