Meyerhans, Andreas
Research Professor
Life & Medical Sciences
Institucio Catalana de Recerca i Estudis Avancats
Spain
Biography
University Education - 1987 PhD in Chemistry, University of Hamburg, Germany. - 1982 Diploma in Chemistry, University of Hamburg, Germany. Professional Positions - Since 2010 ICREA Research Professor at Pompeu Fabra University, Barcelona. - 1998-2009 Full Professor, Saarland University, Germany. - 1990-1998 Assistant Professor, University of Freiburg, Germany. - 1988-1990 Postdoctoral Fellow, Institute Pasteur, Paris, France. - 1987-1988 Postdoctoral Fellow, Institute Biotechnological Research, Braunschweig, Germany.
Research Interest
Infections with non-cytopathic viruses usually have 2 different outcomes. They may be eliminated by host immune responses (acute infections) or they may persist lifelong (persistent infections). Medically important examples are the Hepatitis B virus (HBV), the Human Immunodeficiency virus (HIV) and the Hepatitis C virus (HCV) that in adults usually follow an acute (HBV), a persistent (HIV) or an either acute or persistent (HCV) infection course. My laboratory is interested in: (i) understanding the factors that regulate the decision between an acute versus a persistent infection course, (ii) defining the factors that control the dynamic balance of virus expansion and immune control in persistent infections and (iii) identifying small chemical compounds with broad-spectrum antiviral activities.
Publications
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Sanchez-Merino V, Fabra-Garcia A, Gonzalez N, Nicolas D, MerinoMansilla A, Manzardo C, Ambrosioni J, Schultz A, Meyerhans A, Mascola JR, Gatell JM, Alcami J, Miro JM, Yuste E. Detection of Broadly Neutralizing Activity within the First Months of HIV-1 Infection. J Virol. May 12;90(11):5231-45 (2016).
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Latorre I, Esteve-Sole A, Redondo D, Giest S, Argilaguet J, Alvarez S, Peligero C, Forstmann I, Crespo M, Pascual J, Meyerhans A. Calcineurin and mTOR inhibitors have opposing effects on regulatory T cells while reducing regulatory B cell populations in kidney transplant recipients. Transpl Immunol. Mar;35:1-6 (2016).
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Chen HC, Martinez JP, Zorita E, Meyerhans A, Filion GJ. Position effects influence HIV latency reversal. Nature Structural & Molecular Biology 24(1):47-54 (2017).