Postigo, Antonio
Research Professor
Life & Medical Sciences
Institucio Catalana de Recerca i Estudis Avancats
Spain
Biography
CURRENT POSITION: * ICREA Research Professor. IDIBAPS (Barcelona). * Adjunct Visiting Professor, JG Brown Cancer Center (USA) PAST POSITIONS: * Research Instructor & Special Fellow (Div Mol. Oncology, Washington Univ, USA) * Research Associate and Fellow (Depts. of Cell Biology & Medicine, Washington Univ, USA) * PhD student (Dept. of Immunology, Hosp. de la Princesa, Madrid) FUNDING: * Public agencies: Spanish Ministry of Economy & Competitiveness, AGAUR, European Commission * Private institutions: Leukemia Research Foundation, La Marató de TV3 Foundation, Spanish Association Against Cancer, AVON Breast Cancer Campaign, La Caixa Foundation, Olga Torres Foundation, Academy of Medical and Health Sciences of Catalonia & Balearic Islands
Research Interest
The group investigates the molecular mechanisms regulating gene expression during cell differentiation and cancer. As molecular model we use the ZEB family of transcription factors (ZEB1 and ZEB2) and their different cofactors. Research in the laboratory aims at understanding the expression and function of ZEB factors in stem cell determination, normal cell differentiation, malignant transformation and tumor initiation and progression. Our work involves cell line and human tissue based approaches as well as in vivo mouse models in normal and malignant cells from multiple tissue systems, namely, epithelial, skeletal muscle and hematopoietic.
Publications
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Papadopoulou, V, A POSTIGO, E Sanchez Tillo, AC Porter, S Wagner (2010) ZEB1 and CtBP form a repressive complex at a distal promoter element in the Bcl6 locus, Biochem J , 427(3):541-50.
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Sanchez Tillo E, A Lozano, R Torrent, M Cuatrecasas, E Vaquero, A Castells, P Engel, A POSTIGO *(* corresponding author) (2010), 'ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin remodeling protein BRG1', Oncogene, 29(24):3490-500.
