Salvatella Giralt, Xavier
Research Professor
Experimental Sciences & Mathematics
Institucio Catalana de Recerca i Estudis Avancats
Spain
Biography
He was born in Barcelona, Spain. He obtained his first degree in Chemistry at the University of Barcelona followed by a MSc in Chemical Research at the University of London and a PhD in Organic Chemistry at the University of Barcelona. In 2003, he moved to the University of Cambridge to work as a Research Fellow with Christopher Dobson on the structural and dynamical characterization of proteins. In July 2008, he joined ICREA as a Researcher and the IRB as a Group Leader and in 2013 he became ICREA Research Professor.
Research Interest
A high resolution description of the structure and dynamics of proteins is a very useful tool to study the properties and the function of these important biomacromolecules and, most importantly, to understand how changes in sequence or environment can lead to disease. My research work aims, on the one hand, at developing methods to probe the fluctuations of the structure of proteins by combining experimental data and molecular simulations and, on the other hand, at understanding how changes in such motions relate to the molecular recognition of proteins, to their function and to disease.
Publications
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De Mol E., Fenwick R.B., Phang C. T. W., Buzón V., De la Fuente A., Escobedo A., GarcÃa J., Bertoncini C.W., Estébanez-Perpiñá E., McEwan I.J., Riera A. and Salvatella X. (2016) “EPI-001, a compound active against castration-resistant prostate cancer, targets transactivation unit 5 of the androgen receptor†ACS Chem Biol 11, 2499-2505.
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Guillén-Boixet J., Buzón V., Salvatella X. and Méndez R. (2016) “CPEB4 is regulated during cell cycle by ERK2 and Cdk1-mediated hyperphosphorylation and its assembly into liquid-like droplets†eLife 5, e19298.
