Alicia García Arroyo
Matrix Metalloproteinases in Angiogenesis and Inflammation
National Cardiovascular Research Center Carlos
Alicia G. Arroyo graduated in Medicine from the Complutense University of Madrid in 1989, beginning her scientific training as an undergraduate student in the Center for Biological Research (CIB, CSIC). After this, she specialized in immunology in the Hospital de la Princesa (Madrid), where she did her doctoral thesis on novel mechanisms for the regulation of integrin cellular adhesion receptors in human leukocytes (Universidad Autónoma de Madrid, 1994). In 1995 she moved to Dr. R.O. Hynes' laboratory (MIT, Cambridge, USA), where she analyzed the in vivo function of alpha4 integrins in haematopoiesis and inflammation, in deficient or chimeric mice for these receptors. In 1999 she established her group at the University Hospital of the Princess (as CSIC Scientific Holder). Here she began her studies into the regulation of extracellular matrix metalloproteinases. She joined the CNIC as Group Leader in December 2003. She is currently Senior Group Leader, and her scientific interests are focused on characterizing cellular principles and molecular pathways contributing to new vessel formation in different organs, particularly in the heart, in homeostasis and upon Inflammation and on using this information for designing novel angiotherapies to improve tissue performance and repair.
Udi Y, Grossman M, Solomonov I, Dym O, Rozenberg H, Moreno V, Cuniasse P, Dive V, Arroyo AG, Sagi I. Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody. Structure. 2015 Jan 6;23(1):104-15.
Martin-Alonso M, Garcia-Redondo AB, Guo D, Camafeita E, Martínez F, Alfranca A, Mendez-Barbero N, Pollan A, Sanchez-Camacho C, Denhardt DT, Seiki M. Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice. Circulation research. 2015 May 11:CIRCRESAHA-114.
Arroyo AG, Andrés V. ADAMTS7 in Cardiovascular Disease.