Almudena Ramiro
Investigator
Vascular Biology and Inflammation
National Cardiovascular Research Center Carlos
Spain
Biography
Almudena R Ramiro (Madrid, 1971) graduated in Biochemistry and Molecular Biology at the Autonomous University of Madrid in 1994 and obtained her PhD in Sciences and an Extraordinary Doctoral Thesis at the same university in 2000. In 2001 Ramiro joined the Dr. Michel Nussenzweig's laboratory at Rockefeller University (New York, USA), where she completed his postdoctoral work, funded by the Ministry of Education and Science. During this period her work focused on the function of activation-induced deaminase (AID) in the diversification of antibodies and established the role of AID in the generation of chromosomal translocations. In 2006, Ramiro joined the National Cancer Research Center (CNIO) as Junior Group Manager, where she studied different aspects of germinal center B lymphocytes, such as the regulatory role of microRNAs and the molecular mechanisms that lead to autoimmune pathologies and Cancer. Since 2011, she has been leading the B lymphocyte biology laboratory at the National Center for Cardiovascular Research. Ramiro obtained a Ramón y Cajal contract in 2004 and a CSIC Head Scientist in 2007. In 2006 she was awarded the Biogen Idec Young Researchers Award for her work "Role of genomic instability and p53 in AID-induced c-myc / IgH translocations "Published in the journal Nature. In 2007 Ramiro received an ERC Starting Grant.
Research Interest
Cell Biology and Cardiology
Publications
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Virginia G de Yébenes; Almudena R Ramiro. MicroRNA activity in B lymphocytes.Methods in Molecular Biology (Clifton, N.J.). 667, pp. 177 - 192. 2010. ISSN 1940-6029
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Laura Belver; F Nina Papavasiliou; Almudena R Ramiro. MicroRNA control of lymphocyte differentiation and function.Current Opinion in Immunology. 23 - 3, pp. 368 - 373. 2011. ISSN 1879-0372
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Pablo Pérez Durán; Laura Belver; Virginia G de Yébenes; Pilar Delgado; David G Pisano; Almudena R Ramiro. UNG shapes the specificity of AID-induced somatic hypermutation.The Journal of Experimental Medicine. 209 - 7, pp. 1379 - 1389. 2012. ISSN 1540-9538
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Virginia G de Yébenes; Nahikari Bartolomé Izquierdo; Almudena R Ramiro. Regulation of B-cell development and function by microRNAs.Immunological Reviews. 253-1, pp. 25 - 39. 2013. ISSN 1600-065X