David Sancho Madrid
Investigator
Immunobiology
National Cardiovascular Research Center Carlos
Spain
Biography
fter graduating in Biology (National Prize), David Sancho specializes in Immunology as a resident at La Princesa Hospital (Madrid). While there, he led projects analyzing kinase polarization during the formation of the immune synapse and the immunoregulatory role of C-type lectin CD69 in animal models of inflammation and autoimmunity. After obtaining his PhD from the Universidad Autónoma de Madrid (Molecular Biology department), he took a postdoctoral position at the London Research Institute (Cancer Research UK), where he found a new C-type lectin (DNGR-1 / CLEC9A) that selectively marks the population of human and mouse dendritic cells that cross-present antigens in MHC-I. His work established the function of DNGR-1 / CLEC9A in cross-priming in vivo. On his return to Spain, I established his laboratory at the CNIC, where he has continued to analyze the basis of innate sensing by dendritic cells, the role of different dendritic cell subsets in pathophysiological models and possible applications in new immunotherapy strategies. I have secured the European Research Council Starting Grant (2010) and participates as a partner in a Horizon2020 consortium (2015).
Research Interest
Immunobiology
Publications
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Sanchez-Paulete AR, Cueto FJ, Martinez-Lopez M, Labiano S, Morales-Kastresana A, Rodriguez-Ruiz ME, JureKunkel M, Azpilikueta A, Aznar MA, Quetglas JI, Sancho D* ,§, Melero I* ,§. Cancer immunotherapy with immunomodulatory anti-CD137 and anti-PD-1 monoclonal Abs requires Batf3-dependent DCs. Cancer Discov. 2016 6(1):71-9. NC: 3. IF: 19.45.
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Garaude J* § , AcÃn-Pérez R*, MartÃnez-Cano S, Enamorado M, Ugolini M, Nistal-Villán E, Hervás-Stubbs S, PelegrÃn P, Sander LE, EnrÃquez JA§ , Sancho D§ . Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense. Nat. Immunol. 2016, 17(9):1037-45. IF: 20.004.
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Iborra S§ , MartÃnez-López M, Khouili SC, Enamorado M, Cueto FJ, Conde-Garrosa R, del Fresno C, Sancho D§ . Optimal generation of tissue-resident but not circulating memory T cells during viral infection requires crosspriming by DNGR-1+ dendritic cells. Immunity 2016, DOI: 10.1016/j.immuni.2016.08.019. IF: 24.082
