Francisco Sánchez Madrid
Faculty
Intercellular Communication in the Inflammatory Response
National Cardiovascular Research Center Carlos
Spain
Biography
Dr. Sánchez-Madrid completed his Bachelor's (1976) studies at the University of Seville and a Doctorate (1979) in Sciences at the Universidad Autónoma de Madrid. He started his research career in 1977 at the Center for Molecular Biology addressing the biochemical and functional study of ribosomal proteins of eukaryotic organisms, in the group of Dr. J. P. García Ballesta and David Vázquez. In 1980 he moved to the University of Harvard, to the Department of Pathology, and worked under the direction of Dr. T. A. Springer in the molecular mechanisms of the cytotoxicity of cytotoxic T lymphocytes and the receptors involved in the intercellular adhesion processes. In 1985, he began as an Independent Researcher at the Hospital of the Immunology's Immunology Service, where he has directed a research group on the study of molecular mechanisms that intervene and regulate the processes of adhesion, polarization, migration and leucocyte activation. His research area has spread over the last years to the interactions of lymphocytes with the endothelium, lymphocyte activation and chemokine-directed migration, as well as the role of adhesion and activation receptors, and dendritic cells in the initiation of the Immune response, immunological synapse and regulation of inflammatory response. He has been the Managing Director of the National Biomedicine Plan (2001-1005), President of the Commission for Immunology and Infectious Diseases of the FIS (1998-2000) and Member of the evaluation panel of the ERC (2007-2010). After an agreement with the Universidad Autónoma and the Hospital Universitario de la Princesa, of which he is Professor and Head of the Department of Immunology, in January 2007 he joined the CNIC.
Research Interest
Immunology
Publications
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F. Sánchez-Madrid, F.J. Vidales and J.P.G. Ballesta. "Functional role of acidic ribosomal proteins. Interchangeability of proteins from bacterial and eukaryotic cells". (1981). Biochemistry. 20, 3263-3266.
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F. Sánchez-Madrid, F.J. Vidales and J.P.G. Ballesta. "Effect of phosphorylation on the affinity of acidic proteins from Saccharomyces cerevisiae for the ribosome". (1981). Eur. J. Biochem. 114, 609-613.
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F. Sánchez-Madrid, R. Reyes, P. Conde, and J.P.G. Ballesta. "Acidic ribosomal proteins from eukaryotic cells. Effects on ribosomal function". (1979). Eur. J. Biochem. 98, 409-416.