Guadalupe Sabio Buzo
Assistant Professor
Stress kinases in Diabetes, Cancer and Cardiovascular Diseas
National Cardiovascular Research Center Carlos
Spain
Biography
Guadalupe Sabio graduated from the School of Veterinary Medicine at the Universidad de Extremadura in 2000. Her PhD, under the direction of Dr. Ana Cuenda, was conducted both at the Universidad de Extremadura and at the MRC Protein Phosphorylation Unit in Dundee, UK. Her thesis work demonstrated the redundant function of p38-gamma and p38 delta, and showed that both kinases can phosphorylate SAP97 and SAP90. For her postdoc Guadalupe moved to the University of Massachusetts Medical School (Worcester, MA), to work with Dr. Roger Davis. Her work in this period focused on the tissue-specific roles of JNK1, using mice with conditional deletion of JNK1 in different tissues. Through this work she was able to make important contributions to the understanding of the tissue-specific roles of JNK1 and its implication in the pathogenesis of type II diabetes. Guadalupe returned to Spain in 2009 with a Ramón y Cajal contract to study diseases associated with obesity (diabetes, cardiovascular disease and cancer). She joined the CNIC in 2011.
Research Interest
Diabetes, Cardiovascular disease and Cancer
Publications
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Rajkumar Noubade; Dimitry N Krementsov; Roxana Del Rio; Tina Thornton; Viswas Nagaleekar; Naresha Saligrama; Anthony Spitzack; Karen Spach; Guadalupe Sabio; Roger J Davis; Mercedes Rincon; Cory Teuscher. Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis.Blood. 118 - 12, pp. 3290 - 3300. 22/09/2011. ISSN 1528-0020
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Bárbara González Terán; José R Cortés; Elisa Manieri; Nuria Matesanz; Ãngeles Verdugo; MarÃa E RodrÃguez; Ãgueda González RodrÃguez; Ãngela Valverde; Pilar MartÃn; Roger J Davis; Guadalupe Sabio. Eukaryotic elongation factor 2 controls TNF-# translation in LPS-induced hepatitis.The Journal of clinical investigation. 123 - 1, pp. 164 - 178. 02/01/2013. ISSN 1558-8238
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Monica Imbernon; Daniel Beiroa; MarÃa J Vázquez; Donald A Morgan; Christelle Veyrat Durebex; Begoña Porteiro; Adenis DÃaz Arteaga; Ana Senra; Silvia Busquets; Douglas A Velásquez; Omar Al Massadi; Luis Varela; Marina Gándara; Francisco-Javier López Soriano; RosalÃa Gallego; Luisa M Seoane; Josep M Argiles; Miguel López; Roger J Davis; Guadalupe Sabio; Françoise Rohner Jeanrenaud; Kamal Rahmouni; Carlos Dieguez; Ruben Nogueiras. Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathways.Gastroenterology. 144 - 3, pp. 636 - 649.e6. 03/2013. ISSN 1528-0012
