Jorge Alegre-cebollada
Assistant Professor
Molecular Mechanics of the Cardiovascular System
National Cardiovascular Research Center Carlos
Spain
Biography
Jorge obtained his PhD in Biochemistry in 2008 (Complutense University of Madrid), under the supervision of Prof. Álvaro Martínez del Pozo and Prof. Pepe Gavilanes. After completing his PhD, Jorge joined the laboratory of Prof. Julio Fernández at Columbia University (New York, US). Prof. Fernández pioneered the development of single-molecule techniques by Atomic Force Microscopy (AFM) to examine the mechanical architecture of proteins. During his time in New York, Jorge led several research projects to understand how the elasticity of proteins can be regulated by posttranslational modifications. His research was supported by several foundations and the NIH through a K99/R00 Pathway to Independence grant. In 2014, Jorge joined the CNIC as an Assistant Professor. Jorge was awarded the SBE-33 prize by the Spanish Biophysical Society “for his studies on the importance of mechanical forces on protein dynamics by using single molecule techniques and AFM”. In 2015, Jorge’s trajectory was recognized by a Ramón y Cajal award, the top distinction given by the Spanish Government to early career investigators.
Research Interest
Emergent mechanical properties of proteins in cardiac muscle, Interplay between redox biochemistry and protein mechanics, Intramolecular covalent bonds in proteins: mechanical stability, reactivity, biological role, biosynthesis and Protein biomaterials.
Publications
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Alegre-Cebollada J, Kosuri P, Giganti D, Eckels E, Rivas-Pardo JA, Hamdani N, Warren CM, Solaro RJ, Linke WA, Fernández JM. S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding. Cell. 2014 Mar 13;156(6):1235-46.
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Echelman DJ, Alegre-Cebollada J, Badilla CL, Chang C, Ton-That H, Fernández JM. CnaA domains in bacterial pili are efficient dissipaters of large mechanical shocks. Proceedings of the National Academy of Sciences. 2016 Mar 1;113(9):2490-5.
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Alegre-Cebollada J, Kosuri P, Rivas-Pardo JA, Fernández JM. Direct observation of disulfide isomerization in a single protein. Nature chemistry. 2011 Nov 1;3(11):882-7.
