José Antonio Enríquez Domínguez

Biography

José Antonio Enríquez graduated in Biochemistry and Molecular Biology at the Universidad Autónoma de Madrid and received his doctorate from the University of Zaragoza (UniZar) in 1992. During his thesis he studied several aspects of the biogenesis of DNA mitocondrial (mtDNA). Between 1993 and 1997, I worked with G. Attardi at the California Institute of Technology, where he investigated the pathogenic action of mutated mitocondrial tRNAs. His work during this period helped to define the molecular mechanism underlying this phenomenon and helped to establish a general methodology for the study of mitocondrial tRNAs. This methodology has been applied in studies of mitochondrial biogenesis, as well as in the analysis of diseases related to mtDNA. In 1997 Jose Antonio returned to UniZar to found a research group that has made important contributions in the understanding of biogenesis and bioenergy of the mitocondria, their role in cellular apoptosis, structure and regulation of the chain respiratory and the consequences of alterations pathological of the function mitocondrial; recently describing a possible explanation for how ROS production is affected in murine phenotypes associated with common mtDNA variants. José Antonio, a professor at UniZar since 2007, joined the CNIC in 2009, where he focused on elucidating the molecular mechanisms of mitocondrial dysfunction in cardiovascular disease and ischemic processes.

Research Interest

Cardiology