Juan Miguel Redondo Moya
Investigator
Gene Regulation in Cardiovascular Remodelling&Inflammation
National Cardiovascular Research Center Carlos
Spain
Biography
Dr. Redondo completed his degree in Biochemistry (1982) and Doctorate in Science (1987) by the Autonomous University of Madrid. During his doctoral thesis and postdoctoral training, his work focused on the area of ​​Immunology, especially in processes of activation and transcriptional regulation of T lymphocytes, as well as in the mechanisms of generation of diversity. These works were carried out at the Severo Ochoa Molecular Biology Center (CBMSO), Hospital de la Princesa in Madrid, at Harvard Medical School and at Duke Medical Center. Since 1995 he has directed his own laboratory, initially in the CBMSO (CSIC / UAM) and his area of ​​work was extended to the study of transcriptional regulation in processes of endothelial activation, angiogenesis and inflammation. Much of his work has focused on the study of the regulation and function of the Calcineurin / NFAT signaling pathway. This pathway is not only involved in the processes mentioned above, but also plays an important role in chronic inflammatory diseases, cardiac hypertrophy and ischemic retinopathies. All these physiological or pathological processes are the subject of research by Dr. Redondo's group. After an agreement with the CSIC, of ​​which he is Professor of Research, in November 2001 he joined the CNIC, where he carries out his research as Senior Researcher in the Department of Vascular Biology and Inflammation.
Research Interest
Vascular Biology and Inflammation.
Publications
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Oller J*, Mendez-Barbero E*, Ruiz EJ, Villahoz S, Renard M, Canelas LI, Briones AM, Alberca R, Lozano-Vidal N, Hurle MA, Milewicz D, Evangelista A, Salaices M, Nistal JF, Jimenez-Borreguero LJ, De Backer J, Campanero MR*, Redondo JM*. (JO and NMB contributed equally, MRC and JMR are co-corresponding authors) Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome Nat Med (2017) 23:200-12
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de Carcer G, Wachowicz P, Martinez-Martinez S, Oller J, Mendez-Barbero N, Escobar B, Gonzalez-Loyola A, Takaki T, El Bakkali A, Camara JA, Jimenez-Borreguero LJ, Bustelo XR, Canamero M, Mulero F, de los Angeles Sevilla M, Montero MJ, Redondo JM*, Malumbres M*. (JMR and MM are co-corresponding authors) Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis. Nat Med (2017) Jul 10
