Miguel Manzanares Fourcade
Investigator
Functional Genomics
National Cardiovascular Research Center Carlos
Spain
Biography
Miguel Manzanares studied biology at the Autonomous University of Madrid and obtained his doctorate in biology from the same university in 1993. During the course of his doctoral thesis, in the laboratory of Dr. Rafael Garesse (Department of Biochemistry, UAM), Miguel compared the genetic mechanisms of embryonic segmentation in crustaceans with those of insects. He later performed a six-year postdoctoral stay in Robb Krumlauf's group at the National Institute of Medical Research (London) where he analyzed the role of Hox genes in the development of the nervous system vertebrate, as well as the evolution of the neural crest. Back in Madrid, I joined the Angela Nieto group, at the Cajal Institute (CSIC), where I continued to study the evolution of the neural crest and the role of the genes of the family Snail in this process. In 2001 he established his own group at the Institute of Biomedical Research (CSIC-UAM), where he focused his interest in the study of the origin of evolutionary novels and the functional analysis of the regulation and evolution of the genome. In 2003 I was elected a member of the EMBO-YIP program and at the end of 2007 I joined the Department of Cardiovascular Development Biology of the CNIC.
Research Interest
Cardiovascular Development Biology
Publications
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Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-MarÃn C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH. Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature. 2014 Mar 20;507(7492):371.
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Aguirre LA, Alonso ME, BadÃa-Careaga C, Rollán I, Arias C, Fernández-Miñán A, López-Jiménez E, Aránega A, Gómez-Skarmeta JL, Franco D, Manzanares M. Long-range regulatory interactions at the 4q25 atrial fibrillation risk locus involve PITX2c and ENPEP. BMC biology. 2015 Apr 17;13(1):26.
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Bogdanović O, Smits AH, de la Calle Mustienes E, Tena JJ, Ford E, Williams R, Senanayake U, Schultz MD, Hontelez S, van Kruijsbergen I, Rayon T. Active DNA demethylation at enhancers during the vertebrate phylotypic period. Nature. 2016 Apr 1;201:6.