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Cardiology Experts

Miguel Ángel Del Pozo Barriuso

Investigator
Mechanoadaptation and Caveolae Biology
National Cardiovascular Research Center Carlos
Spain

Biography

Miguel Ángel del Pozo graduated in Medicine and Surgery at the University of Valladolid in 1991, and then pursued a research career while specializing in Immunology at the Hospital de la Princesa in Madrid (1995). The subject of his PhD thesis (Department of Biochemistry, UAM, 1997) was the function of adhesion receptors and chemokines in cell polarization and leukocyte migration in inflammation. During his postdoctoral tenure in the laboratory of Martin Schwartz (The Scripps Research Institute, La Jolla, California, 1998-2002) he contributed to the elucidation of the role of Rho-family GTPases in the regulation of signals intracellular by integrins, factors of growth and mechanical stimuli. He later started his own group as Assistant Professor at Scripps, focusing on integrating signaling and plasma membrane heterogeneity in anchorage-dependent growth. He moved to the CNIC as Assistant Professor in 2004. His group studied the role of integrins, caveolin and Rho / Rac GTPases in mechanotransduction, trafficking in membranes, cell migration and cell growth. In 2004 he received the EURYI Award for Biomedicine (predecessor of the ERC Starting Grant), and in 2005 he was elected by EMBO as a member of the Young Investigator Program (EMBO YIP). He earned a "Scientific Senior Researcher" position at the CSIC in 2005. In 2006 Dr. Del Pozo was promoted to Associate Professor, and Full Professor in 2010. From 2007 to 2010 he was the Head of the Biological Vascular and Inflammation Department at the CNIC. In 2007 the SEBBM awarded him the "Beckman Coulter Prize" for researchers under the age of 40, and in May 2012 he received the "Health Sciences Award" from the Caja Rural de Granada Foundation (VIII edition) and the "Carmen and Severo Ochoa" Award for Research in Molecular Biology (XVIII edition).

Research Interest

Cardiology

Publications

  • Parton RG, Del Pozo MA. Caveolae as plasma membrane sensors, protectors and organizers. Nature reviews Molecular cell biology. 2013 Feb 1;14(2):98-112.

  • Samaniego R, Estecha A, Relloso M, Longo N, Escat JL, Longo-Imedio I, Avilés JA, Del Pozo MÁ, Puig-Kröger A, Sánchez-Mateos P. Mesenchymal contribution to recruitment, infiltration, and positioning of leukocytes in human melanoma tissues. Journal of Investigative Dermatology. 2013 Sep 30;133(9):2255-64.

  • Azegrouz H, Karemore G, Torres A, Alaíz CM, Gonzalez AM, Nevado P, Salmerón A, Pellinen T, del Pozo MA, Dorronsoro JR, Montoya MC. Cell-based fuzzy metrics enhance high-content screening (HCS) assay robustness. Journal of biomolecular screening. 2013 Dec;18(10):1270-83.

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