Vicente Andrés GarcÃa
Faculty
Molecular and Genetic Cardiovascular Pathophysiology
National Cardiovascular Research Center Carlos
Spain
Biography
Vicente Andres obtained his doctorate in Biological Sciences from the University of Barcelona in 1990. During his postdoctoral education at the Children's Hospital of the University of Harvard (1991-1994) and at the St. Elizabeth's Medical Center of the University of Tufts (1994-1995), conducted studies on the role played by homeobox and MEF2 transcription factors in differentiation and cell proliferation processes. At this stage, he began his interest in the area of ​​cardiovascular research. In 1995 he was promoted to Assistant Professor of Medicine at Tufts University and began his career as an independent researcher. Since then, Dr. Andres and his group have studied vascular remodeling during arteriosclerosis and post-angioplasty restenosis. After obtaining a position of Senior Scientist at the Superior Council of Cardiovascular Research, Dr. Andres returned to Spain in 1999 to establish his research group at the Institute of Biomedicine of Valencia, where he worked as Research Professor. Since 2006, his group is a member of the Thematic Network for Cooperative Research in Cardiovascular Diseases (RECAVA). He joined the CNIC in September 2009. In 2010 he was awarded the Doctor Leon Dumont Prize of the Belgian Society of Cardiology
Research Interest
To elucidate molecular and genetic mechanisms that control the initiation and progression of vascular obstructive lesions in the setting of native atherosclerosis and post-angioplasty restenosis, with special emphasis on the regulation of cellular proliferation and gene transcription, To investigate the role of lamin A/C in the regulation of gene expression and signal transduction in health and disease. To investigate molecular and cellular mechanisms underlying physiological ageing as well as HutchinsonGilford progeria syndrome (HGPS), a premature ageing disorder caused by the lamin A mutant progerin which is characterized by excessive cardiovascular disease and premature death.
Publications
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Del Toro R, Chèvre R, RodrÃguez C, Ordóñez A, MartÃnez-González J, Andrés V, Méndez-Ferrer S. Nestin+ cells direct inflammatory cell migration in atherosclerosis. Nature communications. 2016 Sep 2;7.
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Nus M, MartÃnez-Poveda B, MacGrogan D, Chevre R, D’Amato G, Sbroggio M, RodrÃguez C, MartÃnez-González J, Andrés V, Hidalgo A, de la Pompa JL. Endothelial Jag1-RBPJ signalling promotes inflammatory leucocyte recruitment and atherosclerosis. Cardiovascular research. 2016 Aug 5;112(2):568-80.
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Rivera-Torres J, Calvo CJ, Llach A, Guzmán-MartÃnez G, Caballero R, González-Gómez C, Jiménez-Borreguero LJ, Guadix JA, Osorio FG, López-OtÃn C, Herraiz-MartÃnez A. Cardiac electrical defects in progeroid mice and Hutchinson–Gilford progeria syndrome patients with nuclear lamina alterations. Proceedings of the National Academy of Sciences. 2016 Oct 31:201603754.