David Digregorio
European neuroscience institute
Network of European Neuroscience Institutes (ENI-NET)
Spain
Biography
Professor David DiGregorio Department of Neuroscience – The European Neuroscience Institute in Paris, Pasteur
Research Interest
Understanding the complexities of information processing within the brain requires more than just knowing the precise neuronal wiring diagram, it also requires a detailed description of the temporal and spatial dynamics of signal flow between and within single neurons connected in a complex network. This daunting task is simplified by studying small groups of connected neurons, or microcircuits (1). A particularly attractive model microcircuit is that of the cerebellar cortex, because of its ordered, well-defined connectivity and small numbers of neuron types. Nevertheless, surprisingly little is known about how this microcircuit builds upon its well-known synaptic and cellular properties to dynamically integrate and process sensory information, largely because of the difficulty of measuring dynamic activity of many individual synapses or the ensuing postsynaptic signals in fine dendrites.
