José Carlos Dávila Cansino
Professor
Department of Cell Biology, Genetics and Physiology
Universidad de Malaga
Spain
Biography
José Carlos Dávila Cansino holds a PhD in Biological Sciences from the University of Málaga (1983). He has held the following teaching positions: Assistant Professor (1978-1985), Associate Professor (1986-1987), Full Professor (1988-2009). Since 2009 he is Professor of Cell Biology at the University of Málaga. His research career has always been linked to neuroscience, initially with studies on comparative neuroanatomy and development of the nervous system, and in recent years in the field of neurodegeneration. Since 2011, he is part of a research group on Alzheimer's disease, whose objectives are: 1) to understand the molecular and cellular mechanisms involved in neurodegenerative processes; 2) to identify possible biomarkers of the progression of pathology; and 3) To study the efficacy at the preclinical level of new therapeutic treatments. Group web page: http://webdeptos.uma.es/biocel/neuroAD.htm Since 2011 he is a member of the Center for Biomedical Research in Network on Neurodegenerative Diseases (CIBERNED), belonging to the Carlos III Health Institute and designated as a Center of Excellence by the European Union. The group to which it belongs is part of Program 1 dedicated to Alzheimer's Disease and other related dementias ( www.ciberned.es ). He is a member of the PAIDI research group called NEUROPATHOLOGY OF ALZHEIMER'S DISEASE (code: CTS950). Currently, his group also belongs to the Biomedical Research Institute of Malaga (IBIMA) within the consolidated groups of Area 3 of Neurosciences ( www.ibima.eu ).
Research Interest
Molecular and cellular mechanisms involved in neurodegenerative processes; identify possible biomarkers of the progression of pathology
Publications
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GarcÃa-Faroldi G, RodrÃguez CE, Urdiales JL, Pérez-Pomares JM, Dávila JC, Pejler G, Sánchez-Jiménez F, Fajardo I. Polyamines are present in mast cell secretory granules and are important for granule homeostasis. PLoS One. 2010 Nov 30;5(11):e15071.
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Sanchez-Varo R, Trujillo-Estrada L, Sanchez-Mejias E, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, De Castro V, Jimenez S, Ruano D, Vizuete M, Davila JC. Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus. Acta neuropathologica. 2012 Jan 1;123(1):53-70.
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Torres M, Jimenez S, Sanchez-Varo R, Navarro V, Trujillo-Estrada L, Sanchez-Mejias E, Carmona I, Davila JC, Vizuete M, Gutierrez A, Vitorica J. Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus. Molecular neurodegeneration. 2012 Nov 22;7(1):59.
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Trujillo-Estrada L, Jimenez S, De Castro V, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, Navarro V, Sanchez-Varo R, Sanchez-Mejias E, Davila JC, Vizuete M. In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology. Acta neuropathologica communications. 2013 Nov 12;1(1):73.
