Josep Maria De Anta Vinyals
Embriology and Human Anatomy
University of Barcelona
Spain
Biography
Josep Maria de Anta Vinyals Associate Professor from Department of Embriology and Human Anatomy at University of Barcelona. Current projects Genetic susceptibility to coronary neovascularisation in patients with coronary heart disease: an approach based on single nucleotide polymorphism genotyping of genes involved in arteriogenesis and angiogenesis. Fundació La Marató de TV3 (Ref. 20080810). 2009-12. IP. Effect of hypercholesterolemia in Notch signalling pathway during arteriogenesis in mice with hindlimb ischemia. ACESBELL 09. University of Barcelona. 2009-10 Fluid shear stress responses in endothelial progenitor cells from coronary artery patients as determinants of coronary collateral circulation. IP. Fondo de Investigación Sanitaria. Spanish Ministery of Health. Submitted 2010. IP Effect of hypercholesterolemia in Notch signalling pathway during arteriogenesis in mice with hindlimb ischemia and its reversion by simvastatina. Importance in coronary collateral circulation. Grants on Basic Cardiology. Spanish Society of Cardiology. Submitted 2010.
Research Interest
Our main research interest is focused the genetic basis of arteriogenesis in the heart (coronary collateral circulation). We are searching molecular determinants of collateral circulation in coronary artery disease patients. In particular, we are studying the role of functional SNP genotypes in arteriogenic and angiogenic genes, as well as the functional responses of endothelial progenitor cells from coronary artery patients to fluid shear stress in relation with collateral circulation. Other approach is based on an experimental model of arteriogenesis to evaluate the effect of hypercholesterolemia on Notch signaling pathway during arteriogenesis. Our group is also interested in the genetic basis of human anatomical variations, in particular on coronary artery patterning and its importance in myocardial perfusion. This investigation has been supported by several grants from University of Barcelona (ACESBELL).
Publications
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The DNA damage checkpoint is activated during residual tumour cell survival to methotrexate treatment as an initial step of acquired drug resistance.
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Methotrexate resistance in vitro is achieved by a dynamic selection process of tumor cell variants emerging during treatment.
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Low tumor cell density environment yields survival advantage of tumor cells exposed to MTX in vitro.
