Ariizumi Kiyoshi

Biography

Immune responses are tightly regulated in nonlymphoid organs where the ability to defend against infections and cancers should be balanced.  The key process is heavily dependent on proper switching the differentiation program of bone marrow-derived progenitors between the immuno-stimulators and the immunosuppressors.  One-sided differentiation causes hyperactivation or immunosuppression, leading to autoimmune diseases or promoting cancer growth, respectively.  We are studying molecular mechanisms through which myeloid cells (particularly, dendritic cells and macrophages) switch to the suppressors under the pathological conditions of inflammation and cancers, using mouse models (transgenic and gene-disrupted mice) and human clinical samples.  We are also thinking about translational studies to make the results of basic research applicable to the development of new treatments for inflammatory and malignant diseases. 

Research Interest

  Dermatology