Mary Harner

Biography

Mary Harner, Ph.D., Research Investigator II, Leads Discovery & Optimization, Bristol-Myers Squibb Mary is a Research Investigator within the Mechanistic Biochemistry group of Leads Discovery & Optimization at Bristol-Myers Squibb. With a broad training in biophysics and structural biology, Mary uses techniques such as NMR, SPR, TSA and fluorescence to perform fragment screening, hit assessment, and SAR support on relevant targets across multiple therapeutic areas. She also uses biophysical techniques for deeper mechanistic and structural understanding of ligand-binding events. Mary trained as a Damon Runyon Postdoctoral Fellow at Vanderbilt University under the guidance of Stephen W. Fesik, utilizing NMR for fragment screening of challenging targets and X-ray crystallography to drive structure-based drug design efforts. As a graduate student at the University of North Carolina, she studied enzyme conformational dynamics using NMR, X-ray crystallography, and fluorescence methods under the direction of Andrew L. Lee.

Research Interest

 microbiology