Marcus Wilhelmsson
Professor Deputy Head of Division
Chemistry and Chemical Engineering
Chalmers University of Technology
Sweden
Biography
The Wilhelmsson group designs fluorescent base analogues for DNA and RNA as well as develops and utilizes methods using these probes to study biomolecular systems. The research aims at developing molecules and methods that facilitate investigations of structure and dynamics of nucleic acids as well as their interactions with proteins and associated conformational changes. Using this novel toolbox the understanding regarding vital cellular processes like e.g. replication, transcription, gene regulation and RNA folding will increase. Marcus Wilhelmsson is the founder of the conference FB3.
Research Interest
Physical Chemistry, Principles in fluorescence spectroscopy
Publications
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Wilhelmsson LM, Westerlund F, Lincoln P, Nordén B. DNA-Binding of Semirigid Binuclear Ruthenium Complex Δ, Δ-[μ-(11, 11 ‘-bidppz)(phen) 4Ru2] 4+: Extremely Slow Intercalation Kinetics. Journal of the American Chemical Society. 2002 Oct 16;124(41):12092-3.
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Wilhelmsson LM. Fluorescent nucleic acid base analogues. Quarterly reviews of biophysics. 2010 May;43(2):159-83.
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Kumar R, El-Sagheer A, Tumpane J, Lincoln P, Wilhelmsson LM, Brown T. Template-directed oligonucleotide strand ligation, covalent intramolecular DNA circularization and catenation using click chemistry. Journal of the American Chemical Society. 2007 May 30;129(21):6859-64.
