Yang De Marinis
Associate Researcher
Diabetes and Endocrinology
Diabetes Centre Malmoe
Sweden
Biography
Yang de Marinis is an Associate researcher in diabetes in Diabetes Center Malmoe, Sweden
Research Interest
Yang de Marinis current research in Osteopontin (OPN) is a glycoprotein synthesized and secreted by different cell types from various tissues including bone, kidney, smooth muscle and immune organs. OPN promotes cell survival, migration and adhesion by binding to integrins present on the cell surface. Overexpression of OPN has been associated with several physiological and pathological conditions in response to inflammation and other immunologic disorders. Previous studies have revealed that OPN is up-regulated in the serum of type 1 diabetic patients, in diabetic vascular walls and kidneys. The aim of our investigation is to get a better understanding on the protective effect of OPN in islets, as well as the regulation of OPN expression in normal and diabetic islets in association with different regulatory hormones, e.g. GIP and GLP-1.
