Elias Arnér
Professor
Medical Biochemistry and Biophysics
Karolinska Institutet
Sweden
Biography
MD PhD degrees from Karolinska Institutet, through the MD PhD program (LäFo), as one of the 10 students first admitted when the program was launched in 1986.Post doc, Ludwig Maximilian University, Munich, Germany, 1998-1999.Docent in medical biochemistry, 2000.Dean of postgraduate education at Karolinska Institutet, 2005-2007.Head of the biochemistry division at MBB since 2008.Professor in biochemistry with special focus on selenium research in 2009.Executive Editor, BBA General Subjects, since 2008.Editor, JBC, since 2011.Faculty representative at the University Board (Konsistoriet) of Karolinska Institutet, since 2011.
Research Interest
"Role and function of selenoproteins,mammalian thioredoxin system, predominantly the expression, regulation and function of the selenoprotein thioredoxin reductase 1 (TrxR1) and its splice variants, especially in relation to cellular signaling events and in cancer. Another focus of research is the development of production systems for selenoproteins and their potential use in diverse biotechnological applications."
Publications
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Johansson K, Cebula M, Rengby O, Dreij K, Carlström KE, Sigmundsson K, Piehl F, Arnér ES. Cross talk in HEK293 cells between Nrf2, HIF, and NF-κB activities upon challenges with redox therapeutics characterized with single-cell resolution. Antioxidants & redox signaling. 2017 Feb 20;26(6):229-46.
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Peng X, Zhang MQ, Conserva F, Hosny G, Selivanova G, Bykov VJ, Arnér ES, Wiman KG. APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase. Cell death & disease. 2013 Oct;4(10):e881.
