Daniel Scot

Biography

I worked as a postdoctoral researcher in the laboratory of Prof. Andreas Pluckthun in Zurich, Switzerland until the end of 2011. While in Zurich I invented a novel method, called CHESS, for the directed evolution of detergent-resistant membrane proteins. GPCRs stabilised with this method can be produced recombinantly in bacteria, purified and stored in detergents and experimentally probed as if they were highly stable soluble proteins. Such stabilised GPCRs can be applied to X-ray crystallography and NMR for structural studies, but can also be used to probe the molecular determinants of ligand binding, ligand-receptor selectivity and for drug discovery. The CHESS method was spun out into a biotechnology company, G7 Therapeutics, which I co-founded in 2013. G7 Therapeutics is focused on commercial applications of the technology and structure-based drug discovery at stabilised GPCRs.

Research Interest

 Dentistry