Anja Sandström
Senior Lecturer
Medicinal Chemistry, Organic Pharmaceutical Chemistry
Uppsala Biomedical Centre
Sweden
Biography
I received a Master of Science in Pharmacy in 1997. In 1998 I started my dissertation work in Medicinal Chemistry under Prof Anders Hallberg. I became Doctor of Philosophy (Faculty of Pharmacy) in 2003, and was appointed as a Research Scientist in 2003. I became Associate Professor in Medicinal Chemistry in 2009 and was appointed as a University Lecturer in 2011. I have been a Director of Studies since 2008. In 2013, I spent five month at Amherst College, MA, USA, as a STINT fellow within the programme “Excellent in Teaching”. My main research interest concerns design and synthesis drug-like molecules originating from biologically active peptides. In particular, we have worked with development of novel hepatitis C virus (HCV) protease inhibitors with unique resistance profiles, as well as peptidomimetics of the neuropeptide Substance P 1-7 (SP1-7) with potential use against neuropathic pain.
Research Interest
Concerns design and synthesis drug-like molecules originating from biologically active peptides. Development of novel hepatitis C virus (HCV) protease inhibitors with unique resistance profiles, as well as peptidomimetics of the neuropeptide Substance P 1-7 (SP1-7) with potential use against neuropathic pain.
Publications
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Belfrage AK, Gising J, Svensson F, Ã…kerblom E, Sköld C, Sandström A. Efficient and Selective Palladiumâ€Catalysed Câ€3 Urea Couplings to 3, 5â€Dichloroâ€2 (1H)â€pyrazinones. European Journal of Organic Chemistry. 2015 Feb 1;2015(5):978-86.
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Belfrage AK, Abdurakhmanov E, Åkerblom E, Brandt P, Oshalim A, Gising J, Skogh A, Neyts J, Danielson UH, Sandström A. Discovery of pyrazinone based compounds that potently inhibit the drug-resistant enzyme variant R155K of the hepatitis C virus NS3 protease. Bioorganic & medicinal chemistry. 2016 Jun 15;24(12):2603-20.
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Skogh A, Friis SD, Skrydstrup T, Sandström A. Palladium-Catalyzed Aminocarbonylation in Solid-Phase Peptide Synthesis: A Method for Capping, Cyclization, and Isotope Labeling. Organic Letters. 2017 Jun 2.